SYNTHESIS AND CYTOTOXIC ACTIVITY OF PYRANOCOUMARINS OF THE SESELIN AND XANTHYLETIN SERIES

Authors
MAGIATIS P MELLIOU E SKALTSOUNIS AL MITAKU S LEONCE S RENARD P PIERRE A ATASSI G
Citation
P. Magiatis et al., SYNTHESIS AND CYTOTOXIC ACTIVITY OF PYRANOCOUMARINS OF THE SESELIN AND XANTHYLETIN SERIES, Journal of natural products, 61(8), 1998, pp. 982-986
Citations number
16
Categorie Soggetti
Chemistry Medicinal","Plant Sciences","Pharmacology & Pharmacy",Chemistry
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
61
Issue
8
Year of publication
1998
Pages
982 - 986
Database
ISI
SICI code
0163-3864(1998)61:8<982:SACAOP>2.0.ZU;2-J
Abstract
The synthesis of known (3-6) and new (7-10 and 14-22) coumarins in the seselin and xanthyletin series is described. The cytotoxic activity o f compounds 3-22 was carried out in vitro on L-1210 cells. The most ac tive compounds were 9, 16, 18, and 20 in the seselin series and 10, 17 , and 19 in the xanthyletin series. Structure-activity relationships a re discussed.