IDENTIFICATION AND TOTAL SYNTHESIS OF NOVEL FATTY-ACIDS FROM THE CARIBBEAN SPONGE CALYX PODATYPA

Authors
CARBALLEIRA NM PAGAN M RODRIGUEZ AD
Citation
Nm. Carballeira et al., IDENTIFICATION AND TOTAL SYNTHESIS OF NOVEL FATTY-ACIDS FROM THE CARIBBEAN SPONGE CALYX PODATYPA, Journal of natural products, 61(8), 1998, pp. 1049-1052
Citations number
13
Categorie Soggetti
Chemistry Medicinal","Plant Sciences","Pharmacology & Pharmacy",Chemistry
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
61
Issue
8
Year of publication
1998
Pages
1049 - 1052
Database
ISI
SICI code
0163-3864(1998)61:8<1049:IATSON>2.0.ZU;2-8
Abstract
The phospholipid fatty acid composition of the Caribbean sponge Calyx: podatypa was studied, and 85 different fatty acids were identified, i n particular the 11-methylpentadecanoic acid and 10-tricosenoic acid, which have no literature precedence. Structural characterization was a ccomplished by means of gas chromatography-mass spectrometry on their corresponding methyl esters and dimethyl disulfide derivatives. The st ructure of 11-methylpentadecanoic acid was further confirmed by total synthesis (17% overall yield) starting from commercially available 10- hydroxydecanoic acid.