Management strategies for obesity, which include drug therapy, are eme
rging as a consequence of the increasing recognition of the medical se
riousness of obesity. Obesity requires appropriate and effective manag
ement by suitably trained members of a multidisciplinary team, with tr
eatment programmes putting equal importance on weight reduction and it
s maintenance. Such programmes must also take into account the reducti
on in risk from co-morbid conditions after modest weight loss (5-10% o
f initial body weight). The use of an anti-obesity drug may be justifi
ed for patients at risk from obesity where dietary methods, including
exercise and behaviour modification, have failed to achieve a 10% redu
ction in initial body weight after at least three months from the star
t of the episode of managed care. Anti-obesity drugs must be perscribe
d in an appropriate setting, with patients being reviewed on a regular
basis. Essential elements for managed weight loss include, a printed
management programme, appropriate equipment, specified and realistic w
eight-loss goals, documentation of individual patient's health risks,
and clearly defined followup procedures with explicit guidelines for t
he use of drugs and notification of other doctors involved in the pati
ent's care. The process of drug treatment necessitates a system of reg
ular medical audit. Many health-care professionals and lay persons rem
ain sceptical about the scientific value of anti-obesity drugs. The em
ergence of increasingly specific and effective agents underlines the i
mportance of ensuring appropriate use for patients at risk from obesit
y.