A canonical formalism is presented that allows for investigations of q
uantum radiation induced by localized, smooth disturbances of classica
l background fields by means of a perturbation theory approach. For ma
ssless, nonself-interacting quantum fields at zero temperature, we dem
onstrate that the low-energy part of the spectrum of created particles
exhibits a nonthermal character. Applied to QED in varying dielectric
s, the response theory approach facilitates the study of two distinct
processes contributing to the production of photons: the squeezing eff
ect due to space-time varying properties of the medium and the velocit
y effect due to its motion. An alternative quantization method of the
electromagnetic field in linear, inhomogeneous but nondispersive dynam
ical dielectrics is proposed. The generalization of this approach to f
inite temperatures as well as the relation to sonoluminescence is indi
cated.