COMPUTATIONALLY EFFICIENT DYNAMIC MODELING AND SIMULATION OF SIMULATED MOVING-BED CHROMATOGRAPHIC PROCESSES WITH LINEAR ISOTHERMS

This paper presents a new approach for the dynamic simulation of linea r chromatographic processes, in particular, for the simulated moving b ed (SMB) process. The goal of this work was the development of a compu tationally efficient model which is needed for model-based process con trol. Three different modelling and simulation approaches are presente d and compared: an analytical solution of the equilibrium model, a clo sed-form solution of model equations considering both axial dispersion and mass transfer resistance, and a numerical solution of the general rate model. The solutions are compared with respect to complexity, ac curacy and computation time. The new developed closed-form solution gi ves a high accuracy with low computations time. (C) 1998 Elsevier Scie nce Ltd. All rights reserved.