Biotransformation is a broad and growing field of biotechnology and en
compasses both enzymatic and microbial biocatalysis. Progress has been
made in research on the key drivers of biotransformations, including
the isolation and characterization of microbes and their enzymes from,
and their utilization in, extreme environments, the manipulation, alt
eration, and augmentation of metabolic pathways, and the use of combin
atorial biosynthesis and biocatalytic methodologies for new compound d
evelopment.