ROLES OF CYSTEINE PROTEINASES OF TRYPANOSOMES AND LEISHMANIA IN HOST-PARASITE INTERACTIONS

Authors
MOTTRAM JC BROOKS DR COOMBS GH
Citation
Jc. Mottram et al., ROLES OF CYSTEINE PROTEINASES OF TRYPANOSOMES AND LEISHMANIA IN HOST-PARASITE INTERACTIONS, CURRENT OPINION IN MICROBIOLOGY, 1(4), 1998, pp. 455-460
Citations number
47
Categorie Soggetti
Microbiology
Journal title
CURRENT OPINION IN MICROBIOLOGY → ACNP
ISSN journal
13695274
Volume
1
Issue
4
Year of publication
1998
Pages
455 - 460
Database
ISI
SICI code
1369-5274(1998)1:4<455:ROCPOT>2.0.ZU;2-1
Abstract
Trypanosomes and Leishmania contain an abundance of stage-regulated cy steine proteinases encoded by several gene families. Analysis of paras ites rendered defective in cysteine proteinase function, either throug h genetic manipulation or through the use of specific inhibitors, has revealed roles for the enzymes in parasite virulence, in modulation of the host's immune response and in parasite differentiation.