FACILE SYNTHESIS OF A CARBOXYLIC LINKER ON HALOFUGINONE - A METHOD TODERIVATIZE HAPTENS CONTAINING BOTH AMINE AND HYDROXY FUNCTIONALITIES

Authors
ROWE LD BEIER RC ELISSALDE MH STANKER LH STIPANOVIC RD
Citation
Ld. Rowe et al., FACILE SYNTHESIS OF A CARBOXYLIC LINKER ON HALOFUGINONE - A METHOD TODERIVATIZE HAPTENS CONTAINING BOTH AMINE AND HYDROXY FUNCTIONALITIES, Synthetic communications, 23(15), 1993, pp. 2191-2197
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
23
Issue
15
Year of publication
1993
Pages
2191 - 2197
Database
ISI
SICI code
0039-7911(1993)23:15<2191:FSOACL>2.0.ZU;2-Z
Abstract
A succinic acid derivative of halofuginone was synthesized that could be easily bound to carrier proteins for halofuginone-specific antibody production. N-trimethylsilylimidazole was used to protect the hydroxy l group on halofuginone. Hydrolysis after treatment with succinic anhy dride afforded the required derivative.