The understanding and treatment of depression that develops following
traumatic brain injury (TBI) is still unclear and likely to be the res
ult of a complex variety of interacting factors. Past researchers have
developed ways to classify important variables related to patients' d
epression into broad domains such as: Pre-injury assets and liabilitie
s, the nature and severity of brain injury; and reaction to difficulti
es. However, a better conceptualization of the problem is required in
order to guide the assessment and treatment considerations for depress
ed patients with TBI. This review provides this conceptualization by p
ostulating six theoretical relationships between depression and TBI. T
he degree of empirical support provided in the literature for there li
nks is indicated. Research findings suggested that an individual with
TBI is the most susceptible to depression when any of the following co
nditions exist: a pre-existing psychiatric disturbance is exacerbated;
the injury sustained involved the left anterior region of the brain;
and when her individual has poor insight into her deficits, attempts t
o resume her pre-injury roles and experiences significant failure. For
each relationship, a likely outcome is predicted if the recommended t
reatment plan is not conducted. The present conceptualization and trea
tment considerations will be of substantial benefit to clinicians work
ing in the area.