SPONTANEOUS MURINE LUNG ADENOCARCINOMA (P07) - A NEW EXPERIMENTAL-MODEL TO STUDY PARANEOPLASTIC SYNDROMES OF LUNG-CANCER

Authors
DIAMENT MJ GARCIA C STILLITANI I SAAVEDRA VM MANZUR T VAUTHAY L KLEIN S
Citation
Mj. Diament et al., SPONTANEOUS MURINE LUNG ADENOCARCINOMA (P07) - A NEW EXPERIMENTAL-MODEL TO STUDY PARANEOPLASTIC SYNDROMES OF LUNG-CANCER, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2(1), 1998, pp. 45-50
Citations number
45
Categorie Soggetti
Medicine, Research & Experimental
Journal title
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE → ACNP
ISSN journal
11073756
Volume
2
Issue
1
Year of publication
1998
Pages
45 - 50
Database
ISI
SICI code
1107-3756(1998)2:1<45:SMLA(->2.0.ZU;2-U
Abstract
We report the histological and biological behavior characteristics of a lung tumor (P07) that arose spontaneously in a Balb/c mouse. P07 is a moderately to poorly differentiated adenocarcinoma that secretes gra nulocyte-macrophage colony stimulating factor (GMCSF) in culture super natants. This tumor presents some paraneoplastic syndromes, such as le ukocytosis, hypercalcemia and cachexia. Taken together with the periph eral blood leukocyte (PBL) counts and serum calcium levels during s.c. tumor growth and after surgery, this study suggests that P07 may be a useful experimental model to study the biology of lung cancer and par aneoplastic syndromes.