CD95 PREDICTS RESPONSIVENESS TO TRETINOIN IN ACUTE PROMYELOCYTIC LEUKEMIA

Citation
H. Tomizuka et al., CD95 PREDICTS RESPONSIVENESS TO TRETINOIN IN ACUTE PROMYELOCYTIC LEUKEMIA, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 1(1), 1998, pp. 207-211
Citations number
20
Categorie Soggetti
Medicine, Research & Experimental
ISSN journal
11073756
Volume
1
Issue
1
Year of publication
1998
Pages
207 - 211
Database
ISI
SICI code
1107-3756(1998)1:1<207:CPRTTI>2.0.ZU;2-0
Abstract
We describe a predictive marker (CD95) for the responsiveness to treti noin (RA) in acute promyelocytic leukemia (APL). Functional CD95 expre ssion during RA treatment have been observed only in those patients wh o responded to RA. Expression of CD95 (Fas antigen), which plays a maj or role in apoptosis, was determined by fluorescence activated cell so rter (FACS) analysis. APL cases in which no enhancement of CD95 expres sion was observed showed no response to RA and did not obtain complete remission. We propose that CD95 can predict the clinical response to RA probably due to differentiation.