-OXO-4,5,6-TRIHYDROXY-3H-XANTHEN-9-YL)-1-NAPHTHOIC ACID INHIBITS MAPKPHOSPHORYLATION IN ENDOTHELIAL-CELLS INDUCED BY VEGF AND BFGF

Authors
IGARASHI K ISOHARA T KATO T TAKIGAWA K SHIGETA K YAMANO T UNO I
Citation
K. Igarashi et al., -OXO-4,5,6-TRIHYDROXY-3H-XANTHEN-9-YL)-1-NAPHTHOIC ACID INHIBITS MAPKPHOSPHORYLATION IN ENDOTHELIAL-CELLS INDUCED BY VEGF AND BFGF, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2(2), 1998, pp. 211-215
Citations number
25
Categorie Soggetti
Medicine, Research & Experimental
Journal title
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE → ACNP
ISSN journal
11073756
Volume
2
Issue
2
Year of publication
1998
Pages
211 - 215
Database
ISI
SICI code
1107-3756(1998)2:2<211:-AIM>2.0.ZU;2-O
Abstract
Angiogenesis is regulated by various factors. In particular, VEGF and basic FGF are of much importance. We found that -oxo-4,5,6-trihydroxy- 3h-xanthen-9-yl)-1-naphthoic acid inhibited the binding of VEGF to KDR /Flk-1 (VEGF receptor-2) or Flt-1 (VEGF receptor-1) and that it inhibi ted the MAPK phosphorylation in HUVEC induced by VEGF or basic FGF but not by EGF. 8-(3-oxo-4,5,6-trihydroxy-3h-xanthen-9-yl)- 1-naphthoic a cid might be used as an inhibitor of VEGF and basic FGF signal transdu ction.