Objective: To ascertain whether the presence of genital infection adve
rsely affects smear quality. Method: A prospective study of all patien
ts having cytology performed. The presence of genital infection was re
corded and compared with the smear result. Results: The presence of ge
nital infection was not associated with inadequate cytology. Inflammat
ory changes were found in association with symptomatic candidiasis, tr
ichomoniasis, Chlamydia trachomatis infection, primary herpes simplex,
and the finding of 21-30 polymorphs per high power held (averaged ove
r 10 fields) on cervical samples. Inadequate cytology was significantl
y associated with the smear taker. Conclusion: The presence of genital
infection at the time of cytology does not increase the rates of inad
equacy, and opportunistic cytology should not be deferred as the patie
nt may default from further appointments.