SYNTHESIS OF PYRROLOBENZODIAZEPINES VIA THE PIFA OXIDATION OF AMINES - SYNTHESIS OF 8-DEOXY DC-81

Authors
KRAUS GA MELEKHOV A
Citation
Ga. Kraus et A. Melekhov, SYNTHESIS OF PYRROLOBENZODIAZEPINES VIA THE PIFA OXIDATION OF AMINES - SYNTHESIS OF 8-DEOXY DC-81, Tetrahedron, 54(39), 1998, pp. 11749-11754
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
54
Issue
39
Year of publication
1998
Pages
11749 - 11754
Database
ISI
SICI code
0040-4020(1998)54:39<11749:SOPVTP>2.0.ZU;2-I
Abstract
PIFA can be used to introduce the imine moiety into a precursor to the pyrrolobenzodiazepines in 62% yield. This oxidation completes an effi cient four-step synthesis of 8-deoxy DC-81. (C) 1998 Elsevier Science Ltd. All rights reserved.