SCABRONINE-B, SCABRONINE-C, SCABRONINE-D, SCABRONINE-E AND SCABRONINE-F, NOVEL DITERPENOIDS SHOWING STIMULATING ACTIVITY OF NERVE GROWTH FACTOR-SYNTHESIS, FROM THE MUSHROOM SARCODON SCABROSUS

Novel cyathane-type diterpenoids, scabronines B-F (1-5) were isolated from the mushroom Sarcodon scabrosus. Their structures were determined by interpretation of their spectral data and chemical transformation. The absolute stereochemistry of scabronine C (2) was confirmed by the exciton chirality method, and the chemical transformation of scabroni nes B, C and D (1, 2 and 3) clarified their absolute structures. The a bsolute stereochemistries of scabronines E and F (4 and 5) were determ ined by comparison of their CD spectra with that of erinacine A (7). A mong these compounds, scabronines B, C and E (1, 2 and 4) exhibit stim ulating activity of the synthesis of a nerve growth factor. (C) 1998 E lsevier Science Ltd. All rights reserved.