CONGENITAL BICUSPID AORTIC-VALVE - ANALYSIS OF 63 SURGICAL CASES

Background and aims of the study: This study reports the clinicopathol ogic characteristics of congenital bicuspid aortic valves necessitatin g surgical intervention. Methods: Among 374 aortic valve procedures du ring the past 15 years, 63 cases of bicuspid aortic valve were encount ered. Patients included 45 males and 18 females; mean age was 53 years (range: 14 to 76 years). Results: Thirty-two patients demonstrated ao rtic stenosis (AS), 27 aortic regurgitation (AR), and four had both co nditions. Patients with AR were significantly younger than those with AS (45 +/- 13 versus 60 +/- 11 years; p < 0.01). Histologic study of t he excised valve disclosed severe myxoid degeneration in 16 of 27 pati ents with AR. These patients underwent surgery at a younger age than t he other 11 with calcification and endocarditis (40 +/- 13 versus 52 /- 10 years; p = 0.01). Based on the macroscopic appearance, the lesio ns were divided into those with (n = 38) and without (n = 25) raphe. T wenty-one patients (55%) in the former group demonstrated AR, whereas 19 (76%) in the latter group demonstrated AS. Patients with raphe were significantly younger at the time of surgery than those without raphe (50 +/- 15 versus 57 +/- 11 years; p = 0.02). As a complication, asce nding aortic aneurysm was observed in six patients. Conclusions: In a bicuspid aortic valve, calcification with stenosis commonly occurs in most older patients. However, in some young adult patients with raphe, AR may result front myxoid degeneration. The presence of raphe in the bicuspid valve appears to have a significant influence on valve hemod ynamics.