TOTAL VARIABLE IMMUNODEFICIENCY IN ADULTS AND PROBLEMS OF ITS IMMUNOTHERAPY

Aim. Clinicoimmunological study of adult patients with prevailing defe ct of humoral immunity, development of diagnostic criteria and treatme nt of this disease. Materials and methods. Clinical, immunological and microbiological examinations were made in 68 patients with defects of antibody formation. Results, Total variable immunodeficiency (TVID), selective deficiency of IgA, congenital agamma-globulinemia, hyper-IgM -syndrome were detected in 74, 13, 10 and 3% of patients, respectively . TVID was frequently associated with respiratory, chronic ENT and gas trointestinal diseases, low CD4(+) and high CD8(+) levels. The respons e was achieved with combined therapy: antibacterial treatment+immunoco rrection +differentiated replacement with plasma or immunoglobulins. C onclusion. In choice of immunotherapy of TVID patients it is necessary to consider parameters of immunogram. Intravenous administration of i mmunoglobulin preparations provided the highest effect in good safety.