STRUCTURES INVOLVING SODIUM HYALURONATE DURING EVAPORATION OF EMULSION FORMULATIONS

Oil-in-water emulsions of sodium hyaluronate stabilized by nonionic su rfactants were analyzed for structural changes during evaporation. The results were compared to the structures found in the appropriate phas e diagrams. The results demonstrated the sodium hyaluronate water cont ent to be extremely high compared to the water content of the water/su rfactant lamellar liquid crystal during evaporation and also revealed the sodium hyaluronate to give rise to new association structures at l ow water contents during evaportation. These structures could not be r eproduced by mixing of the components at the corresponding composition .