THE DF-1 CHICKEN FIBROBLAST CELL-LINE - TRANSFORMATION-INDUCED BY DIVERSE ONCOGENES AND CELL-DEATH RESULTING FROM INFECTION BY AVIAN-LEUKOSIS VIRUSES

Authors
HIMLY M FOSTER DN BOTTOLI I IACOVONI JS VOGT PK
Citation
M. Himly et al., THE DF-1 CHICKEN FIBROBLAST CELL-LINE - TRANSFORMATION-INDUCED BY DIVERSE ONCOGENES AND CELL-DEATH RESULTING FROM INFECTION BY AVIAN-LEUKOSIS VIRUSES, Virology (New York, N.Y. Print), 248(2), 1998, pp. 295-304
Citations number
74
Categorie Soggetti
Virology
Journal title
Virology (New York, N.Y. Print) → ACNP
ISSN journal
00426822
Volume
248
Issue
2
Year of publication
1998
Pages
295 - 304
Database
ISI
SICI code
0042-6822(1998)248:2<295:TDCFC->2.0.ZU;2-Z
Abstract
DF-1 is a continuous cell line of chicken embryo fibroblasts. The cell s are free of endogenous sequences related to avian sarcoma and leukos is viruses and have normal fibroblastic morphology. DF-1 cells support the replication of avian retroviruses; diverse oncogenes induce foci of oncogenic transformation on monolayers of DF-1, and avian leukosis viruses of envelope subgroups B, D, and C induce cell death and form p laques. The new cell line will greatly facilitate studies on oncogenic transformation and cell killing by avian viruses. (C) 1998 Academic P ress.