A uniform and practical classification and staging system for melanoma
must exist and be widely adopted if useful comparisons between differ
ent treatment centers and databases are to be made. This article revie
ws the 1992 American Joint Committee on Cancer pTNM staging system. In
this classification, localized disease without regional nodal involve
ment is defined as stage I or II, depending on the tumor thickness of
the primary melanoma. Regional lymph node involvement and/or in-transi
t metastasis is defined as stage III, and systemic metastatic disease
is defined as stage IV.