This article summarizes recent and ongoing efforts in the area of adju
vant interferon treatment for cutaneous melanoma. Interferon therapy t
argets the immune system in an attempt to cure high-risk melanoma. Mor
e than a decade of interferon research has culminated in the successfu
l application of interferon-alpha-2b in melanoma, with significantly p
rolonged survival in patients at high risk for recurrence after surgic
al resection.