ETHYLENE-GLYCOL POISONING IN A CHILD TREATED WITH 4-METHYLPYRAZOLE

Objectioe. The alcohol dehydrogenase inhibitor 4-methylpyrazole (4-MP) is a new antidote of ethylene glycol (EG) intoxication. The purpose o f the present case report was to demonstrate 4-MP efficiency in EG poi soning in a 4-year-old child. Method and Results. 4-MP Treatment was p erformed 7 hours after EG ingestion. Plasma EG and 4-MP concentrations were measured 2 hours after each infusion of 4-MP. Plasma 4-MP concen trations were in the range of the values reported to block EG metaboli sm. The efficiency of 4-MP treatment was confirmed by the rapid correc tion of metabolic acidosis without alkalization and by the increase in EG half-life. No adverse effect of 4-MP was observed. Conclusion. Thi s child ingested a potentially lethal dose of EG despite a high concen tration of bittering agent in antifreeze. EG poisoning was treated eff iciently by 4-MP without recourse to hemodialysis.