NALTREXONE TREATMENT ATTENUATES THE INHIBITORY EFFECT OF NICOTINE TREATMENT ON SERUM LH IN RATS

Authors
HODSON CA DAVENPORT A PRICE G BURDEN HW
Citation
Ca. Hodson et al., NALTREXONE TREATMENT ATTENUATES THE INHIBITORY EFFECT OF NICOTINE TREATMENT ON SERUM LH IN RATS, Life sciences, 53(10), 1993, pp. 839-846
Citations number
20
Categorie Soggetti
Biology,"Medicine, Research & Experimental
Journal title
Life sciences → ACNP
ISSN journal
00243205
Volume
53
Issue
10
Year of publication
1993
Pages
839 - 846
Database
ISI
SICI code
0024-3205(1993)53:10<839:NTATIE>2.0.ZU;2-C
Abstract
The hypothesis that endogenous opioids might have a role in mediating the suppressive effects of nicotine on serum LH concentrations in rats was investigated. Naltrexone treatment prevented the inhibitory effec t of high doses of nicotine on serum LH concentrations. Nicotine treat ment also prevented the stimulatory effect of naltrexone on serum LH c oncentrations. These results suggest that the inhibitory effects of ni cotine on serum LH concentrations involve an opioidergic component.