SYNTHESIS, HALOGENATION AND STRUCTURAL CHARACTERIZATION OF (Z)-1-[2-(TRIPHENYLSTANNYL)VINYL]-1-CYCLODODECANOL

Synthesis and characterization of Z)-1-[2-(triphenylstannyl)vinyl]-1-c yclododecanol, c-(OH2)(11)C(OH)CH=CHSnPh3, are reported, together with its halogenation by I-2, Br-2 and ICl to yield derivatives of the typ es c-(CH2)(11)C(OH)CH=CHSnPh3-nXn (n=1, 2; X=I, Br, Cl, respectively). The molecular structures of two compounds have been determined by X-r ay diffraction analysis. The tin atom exhibits a distorted tetrahedral geometry in the crystal of (2)-1-[2- (triphenylstannyl)vinyl]-1-cyclo dodecanol, but a trigonal bipyramidal geometry in the monoiodo-derivat ive (2)-1-[2- (diphenyliodostannyl)vinyl]-1-cyclododecanol and other d erivatives, in which significant intramolecular coordinative interacti on HO-->Sn is observed. And the formation of a five-membered tin conta ining ring is significant for their antitumour activities.