M. Ihara et al., PRIMARY ANTIPHOSPHOLIPID SYNDROME WITH RECURRENT TRANSIENT ISCHEMIC ATTACKS - REPORT OF A CASE AND ITS SUCCESSFUL TREATMENT, Internal medicine, 37(8), 1998, pp. 704-707
A 35-year-old woman was admitted to our hospital with complaints of a
two-year history of recurrent, daily episodes of transient ischemic at
tacks; the symptoms consisted of scotoma of her left eye, vertical dip
lopia, and paresthesia of her right arm. The presence of lupus anticoa
gulants and anticardiolipin antibodies led to the diagnosis of antipho
spholipid syndrome (APS), After thrombotest values had decreased to 30
% (international normalized ratio: 1.5) with warfarin, her symptoms di
d not recur. This suggests that anticoagulant therapy is effective for
the prevention of recurrence of ischemic events complicated by primar
y APS, even when they occur repeatedly.