PROANTHOCYANIDINS FROM BARLEY BRAN POTENTIATE RETINOIC ACID-INDUCED GRANULOCYTIC AND SODIUM BUTYRATE-INDUCED MONOCYTIC DIFFERENTIATION OF HL60 CELLS

Authors
TAMAGAWA K FUKUSHIMA S KOBORI M SHINMOTO H TSUSHIDA T
Citation
K. Tamagawa et al., PROANTHOCYANIDINS FROM BARLEY BRAN POTENTIATE RETINOIC ACID-INDUCED GRANULOCYTIC AND SODIUM BUTYRATE-INDUCED MONOCYTIC DIFFERENTIATION OF HL60 CELLS, Bioscience, biotechnology, and biochemistry, 62(8), 1998, pp. 1483-1487
Citations number
24
Categorie Soggetti
Biology,Agriculture,"Biothechnology & Applied Migrobiology","Food Science & Tenology
Journal title
Bioscience, biotechnology, and biochemistry → ACNP
ISSN journal
09168451
Volume
62
Issue
8
Year of publication
1998
Pages
1483 - 1487
Database
ISI
SICI code
0916-8451(1998)62:8<1483:PFBBPR>2.0.ZU;2-D
Abstract
Polyphenol extract from barley bran (BPE) induced nitro blue tetrazoli um (NBT) reducing activity and alpha-naphthyl butyrate esterase activi ty in HL60 human myeloid leukemia cells. Because BPE induced the bioch emical markers of HL60 cell differentiation, we investigated the effec ts of proanthocyanidins isolated from BPE on the HL60 cell differentia tion of HL60 cells. Prodelphinidin B-3, T1, T2, and T3 induced 26-40% NET-positive cells and 22-32% alpha-naphthyl butyrate esterase-positiv e cells. Proanthocyanidins potentiated retinoic acid (all-trans-retino ic acid)-induced granulocytic and sodium butyrate-induced monocytic di fferentiation in HL60 cells.