ACTIVITY OF LIPOSOMAL AMPHOTERICIN-B WITH PROLONGED CIRCULATION IN BLOOD VERSUS THOSE OF AMBISOME AND FUNGIZONE AGAINST INTRACELLULAR CANDIDA-ALBICANS IN MURINE PERITONEAL-MACROPHAGES

Authors
VANETTEN EWM VANVIANEN W HAK J BAKKERWOUDENBERG IAJM
Citation
Ewm. Vanetten et al., ACTIVITY OF LIPOSOMAL AMPHOTERICIN-B WITH PROLONGED CIRCULATION IN BLOOD VERSUS THOSE OF AMBISOME AND FUNGIZONE AGAINST INTRACELLULAR CANDIDA-ALBICANS IN MURINE PERITONEAL-MACROPHAGES, Antimicrobial agents and chemotherapy, 42(9), 1998, pp. 2437-2439
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
42
Issue
9
Year of publication
1998
Pages
2437 - 2439
Database
ISI
SICI code
0066-4804(1998)42:9<2437:AOLAWP>2.0.ZU;2-J
Abstract
Activity against intracellular Candida albicans was assessed in C. alb icans-infected murine peritoneal macrophages exposed to long-circulati ng pegylated amphotericin B liposomes (PEG-AMB-LIP), AmBisome, or Fung izone. The level of antifungal activity of Fungizone is much higher th an that of AmBisome or PEG-AMB-LIP, while PEG-AMB-LIP and AmBisome sho w equivalent activity levels. Previous exposure of uninfected macropha ges to PEG-AMB-LIP or AmBisome is advantageous for intracellular antif ungal activity.