SYNERGISM BETWEEN )-BETA-D-GLUCOPYRANOSYL-(1-3)-BETA-D-GLUCOPYRANOSE GLUCAN AND CEFAZOLIN IN PROPHYLAXIS OF STAPHYLOCOCCAL WOUND-INFECTION IN A GUINEA-PIG MODEL
Ab. Kaiser et Ds. Kernodle, SYNERGISM BETWEEN )-BETA-D-GLUCOPYRANOSYL-(1-3)-BETA-D-GLUCOPYRANOSE GLUCAN AND CEFAZOLIN IN PROPHYLAXIS OF STAPHYLOCOCCAL WOUND-INFECTION IN A GUINEA-PIG MODEL, Antimicrobial agents and chemotherapy, 42(9), 1998, pp. 2449-2451
To determine whether the infection-preventing capability of the neutro
phil-activating agent )-beta-D-glucopyranosyl-(1-3)-beta-D-glucopyrano
se glucan (PGG-glucan) can be enhanced with antibiotic prophylaxis, we
administered PGG-glucan and cefazolin, alone and in combination, to g
uinea pigs inoculated,vith isolates of staphylococci. Guinea pigs rece
iving both PGG-glucan and cefazolin had 50% infective doses that were
8- to 20-fold higher than those obtained with cefazolin alone and 100-
to 200-fold higher than those obtained with PGG-glucan alone. PGG-glu
can and cefazolin are synergistic in their ability to prevent staphylo
coccal wound infection.