Mj. Fonseca et al., PHYSICOCHEMICAL STUDY OF HYDROPHOBIC DERIVATIVES OF COLLAGEN FRAGMENTS, Journal of colloid and interface science (Print), 205(1), 1998, pp. 141-148
Collagen fragments of molecular weights ranging from 700 to 3500 were
prepared and allowed to react with hexyl and lauryl aldehydes in order
to obtain derivatives of different hydrophobicities. Lauryl collagen
forms, in aqueous solutions, aggregates that have low tendency to inte
ract with phospholipid mono and bilayers, with reduced surface activit
y but the ability to entrap ANS molecules. The hexyl derivative shows
a greater hydrophobicity in terms of surface activity and interaction
with lipids but a lower ability to incorporate ANS. Underivatized coll
agen shows no lipid interaction in any of the experiments. (C) 1998 Ac
ademic Press.