HELICAL STEREOREGULAR ARTIFICIAL GLYCOCONJUGATE POLYMERS BASED ON POLY(PHENYLACETYLENE) BACKBONE - SYNTHESIS AND MOLECULAR RECOGNITION WITHLECTIN

Stereoregular poly(phenylacetylene)s bearing pendant lactose and cello biose moiety were synthesized by polymerization of beta-N-glycosylated 4-ethynylbenzamides with [Rh(nbd)Ci](2) (nbd=norbornadiene) as initia tor. The glycoconjugate polymer possessed alternating double bond back bone with cis-transoidal regioregularity and helical conformation. Inh ibition assay of hemagglutination revealed that galactose-specific lec tin efficiently bound to the stereoregular helical glycopolymer bearin g lactose, but the binding was not so strong as that of the correspond ing flexible glycoconjugate polystyrene.