Background. Pathological gambling is becoming an increasing problem in
the United States as the number of legalized gambling establishments
grows. To examine vulnerability to pathological gambling, we estimated
the familial contributions (i.e. inherited factors and/or experiences
shared by twin siblings during childhood) to DSM-III-R pathological g
ambling symptoms and disorder. Methods. Data were obtained from a tele
phone interview performed in 1991-92 utilizing the Diagnostic Intervie
w Schedule Version III-Revised. Interviews were administered to 6718 m
embers of the nationally distributed Vietnam Era Twin Registry of male
-male monozygotic and dizygotic twin pairs who served in the military
during the Vietnam era. Results. Inherited factors explain between 35%
(95% CI: 28% 42%) and 54% (95% CI 39%, 67%) of the liability for the
five individual symptoms of pathological gambling behavior that could
be estimated statistically. In addition, familial factors explain 56%
(95% CI: 36%, 71%) of the,report of three or more symptoms of patholog
ical gambling, and 62% (95% CI: 40%, 79%) of the diagnosis of patholog
ical gambling disorder (four or more symptoms). Conclusions. Familial
factors have an important influence on risk for pathological gambling
behavior. The increasing access To legalized gambling is likely to res
ult in a higher prevalence of Pathological gambling behavior among ind
ividuals who are more vulnerable because of familial factors.