We report herein the case of a 70-year-old woman with enteropathy acco
mpanied by protein loss, the cause of which was found to be thrombophl
ebitis of the mesenteric vein. The patient was admitted to our hospita
l for investigations to determine the cause of hypoproteinemia, She ha
d suffered an episode of left abdominal pain with high fever and vomit
ing lasting 10 days, 8 months prior to her admission. She also had a 6
-year history of uncontrolled diabetes. The alpha(1)-antitrypsin clear
ance was 85.7ml/day, suggesting protein-losing enteropathy. A scintigr
aphy with 99m-technetium-human serum albumin disclosed protein leakage
into the intestine. X-Rays and computed tomography showed a stenotic
and thickened area of small intestine 50 cm in length. Thus, a laparot
omy was performed to resect this part of the intestine which was found
to have undergone past thrombophlebitic changes. Following the operat
ion, the a, antitrypsin clearance decreased to within the normal range
and the patient gained 5kg in weight.