By most measures, child and adolescent depression is much like and con
tinuous with adult depression. Aggregating all available data, much of
which is relatively new it seems most likely that noradrenergic and m
ixed serotonergic/noradrenergic tricyclic antidepressants are ineffect
ive in child and adolescent depression, whereas serotonergic antidepre
ssants (e.g., selective serotonin reuptake inhibitors) are probably ef
fective. (C) 1998 Society of Biological Psychiatry.