KINETICS OF A DRUG-RELEASE FROM A DELAYED RELEASE DEVICE

Citation
A. Bichara et al., KINETICS OF A DRUG-RELEASE FROM A DELAYED RELEASE DEVICE, European Polymer Journal, 34(9), 1998, pp. 1283-1293
Citations number
14
Categorie Soggetti
Polymer Sciences
Journal title
ISSN journal
00143057
Volume
34
Issue
9
Year of publication
1998
Pages
1283 - 1293
Database
ISI
SICI code
0014-3057(1998)34:9<1283:KOADFA>2.0.ZU;2-G
Abstract
Reaction of sodium salt of benzoic acid with methacryloyl chloride pro vides an anhydride which is polymerized by the radical method or copol ymerized with various percentages of ethylene glycol dimethacrylate to obtain crosslinked products. Hydrolysis reactions of the resulting po lymers were carried out in various aqueous solutions and the rate of r elease of benzoic acid (simulator of drug) seems to depend both on the percentages of crosslinking comonomer and on the pH of the solution. A model of this delayed release of benzoic acid is also proposed. (C) 1998 Elsevier Science Ltd. All rights reserved.