SYNTHESIS OF LIPOPEPTIDES USING HYDRAZONE CHEMICAL LIGATION

Authors
MELNYK O BOSSUS M DAVID D ROMMENS C GRASMASSE H
Citation
O. Melnyk et al., SYNTHESIS OF LIPOPEPTIDES USING HYDRAZONE CHEMICAL LIGATION, The journal of peptide research, 52(3), 1998, pp. 180-184
Citations number
18
Categorie Soggetti
Biology
Journal title
The journal of peptide research → ACNP
ISSN journal
1397002X
Volume
52
Issue
3
Year of publication
1998
Pages
180 - 184
Database
ISI
SICI code
1397-002X(1998)52:3<180:SOLUHC>2.0.ZU;2-N
Abstract
In this paper we report that a hydrazinopeptide synthesized using soli d-phase N-electrophilic amination with N-Boc-3-(4-cyanophenyl)oxazirid ine reacted with a lipophilic peptide aldehyde to give the correspondi ng hydrazone plus an unexpected 1,3,4-oxadiazolidinopeptide containing two peptide aldehyde units. This methodology allows the synthesis of large lipopeptides.