SURVEILLANCE FOR CREUTZFELDT-JAKOB-DISEASE AMONG PERSONS WITH HEMOPHILIA

BACKGROUND: Although Creutzfeldt-Jakob disease (CJD) has been shown to be transmissible through blood components in rodent models, no human blood-to-blood transmission has been documented. If blood transmission were possible in humans, persons with hemophilia in the United States would be at higher risk of contracting CJD, because they receive larg e numbers of blood components. Nearly one-half of the hemophilia popul ation contracted HIV in the 1980s, and many of these people have since died with neurologic complications. This study investigated whether s ome hemophilia patients with neurologic disorders may have died with C JD. STUDY DESIGN AND METHODS: Hemophilia treatment Centers across the United States were invited to participate in this retrospective survei llance study. The centers were asked to send any available formalin-fi xed paraffin block brain samples from hemophilia decedents. Slides wer e prepared at the Centers for Disease Control and Prevention and revie wed by three expert neuropathologists. Two slides were stained for the prion protein at the request of one of the neuropathologists. RESULTS : Specimens from 24 decedents with genetic bleeding disorders were col lected and reviewed. The panel found no evidence of CJD in any of the specimens. CONCLUSIONS: Although the study sample is small, these resu lts support the growing evidence that CJD is not being transmitted in the nation's blood supply.