Partial blindness after brain injury has been considered non-treatable
. To evaluate whether patients with visual-field defects can profit fr
om computer-based visual restitution training (VRT), two independent c
linical trials were conducted using patients with optic nerve (n = 19)
or post-chiasmatic brain injury (n = 19). In post-chiasma patients, V
RT led to a significant improvement (29.4%) over baseline in the abili
ty to detect visual stimuli; in optic nerve patients, the effects were
even more pronounced (73.6% improvement). Visual-field enlargements w
ere confirmed by the observation of a visual-field expansion of 4.9 de
grees-5.8 degrees of visual angle and improved acuity in optic nerve p
atients. Ninety five percent of the VRT-treated patients showed improv
ements, 72.2% confirmed visual improvements subjectively. Patients rec
eiving a placebo training did not show comparable improvements. In con
clusion, VRT with a computer program improves vision in patients with
visual-field defects and offers a new, cost-effective therapy for part
ial blindness.