AN EFFICIENT SUBSTITUTION-REACTION FOR THE PREPARATION OF THYROID-HORMONE ANALOGS

Authors
YOSHIHARA HAI CHIELLINI G MITCHISON TJ SCANLON TS
Citation
Hai. Yoshihara et al., AN EFFICIENT SUBSTITUTION-REACTION FOR THE PREPARATION OF THYROID-HORMONE ANALOGS, Bioorganic & medicinal chemistry, 6(8), 1998, pp. 1179-1183
Citations number
11
Categorie Soggetti
Biology,"Chemistry Medicinal","Chemistry Inorganic & Nuclear
Journal title
Bioorganic & medicinal chemistry → ACNP
ISSN journal
09680896
Volume
6
Issue
8
Year of publication
1998
Pages
1179 - 1183
Database
ISI
SICI code
0968-0896(1998)6:8<1179:AESFTP>2.0.ZU;2-4
Abstract
The substitution of the sterically hindered carbon of the potent thyro id hormone agonist, GC-1, was effected by a reaction based on the solv olysis of the benzylic hydroxyl group. The reaction was found to proce ed in high yield with a variety of nucleophiles including alcohols, th iols, allyl silanes and electron-rich aromatic compounds, providing a convenient route to the synthesis of new thyroid hormone analogues. (C ) 1998 Elsevier Science Ltd. All rights reserved.