PROTEIN CROSS-LINKING MEDIATED BY METALLOPORPHYRINS

Authors
CAMPBELL LA KODADEK T BROWN KC
Citation
La. Campbell et al., PROTEIN CROSS-LINKING MEDIATED BY METALLOPORPHYRINS, Bioorganic & medicinal chemistry, 6(8), 1998, pp. 1301-1307
Citations number
30
Categorie Soggetti
Biology,"Chemistry Medicinal","Chemistry Inorganic & Nuclear
Journal title
Bioorganic & medicinal chemistry → ACNP
ISSN journal
09680896
Volume
6
Issue
8
Year of publication
1998
Pages
1301 - 1307
Database
ISI
SICI code
0968-0896(1998)6:8<1301:PCMBM>2.0.ZU;2-8
Abstract
A biomimetic protein cross-linking reaction is described which employs oxidatively-activated manganese and iron porphyrins as the reactive s pecies. A wide range of proteins cross-link under these conditions, bu t only if they are intimately associated in solution. The reaction is rapid, efficient, and will be useful for the suprastructural analysis of multiprotein complexes. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.