I. Alexandrov et al., SODIUM-BUTYRATE SUPPRESSES APOPTOSIS IN HUMAN BURKITT LYMPHOMAS AND MURINE PLASMACYTOMAS BEARING C-MYC TRANSLOCATIONS, FEBS letters, 434(1-2), 1998, pp. 209-214
We report that sodium butyrate, a natural product of fiber degradation
by colonic bacteria, markedly suppresses c-Myc-mediated apoptosis ind
uced in murine plasmacytomas and human Burkitt lymphomas by growth fac
tor deprivation, but not in cell lines devoid of c-myc translocations.
Attenuation of cell death is associated with downregulation of the re
arranged c-myc and activation of pRb via its dephosphorylation, We sug
gest that in vivo sodium butyrate may play an important role in plasma
cytomagenesis by supporting the survival of cells,vith c-myc transloca
tions, which otherwise mould be eliminated by the lack of growth facto
rs. (C) 1998 Federation of European Biochemical Societies.