SYNTHESIS OF SOME CHROMANONE DERIVATIVES AND THE USE OF DNA IN EVALUATION OF THEIR BIOLOGICAL-ACTIVITY

myl-7-hydroxy-5-methoxy-2-pentamethylenechromanone (2) was prepared fr om the naturally occurring ''Visnagin'' and condensed with benzil, o-p henylenediamine and 3,4-diaminobenzophenone to give the corresponding imidazolylchromanone derivatives 3-5. Knoevenagel reaction of compound 2 with different active methylene compounds afforded benzodipyranone derivatives 12a-c which may be considered as analogues to the naturall y occurring ''Xanthyletin and Graveolone Compounds''. The structural f ormula of the new compounds were established by using different method s for their preparation in addition to the instrumental analyses. Some compounds in this study were biologically evaluated for their ability to bind to DNA.