Hh. Seltzman et al., PROTECTION OF THE ALLYLIC ALCOHOL DOUBLE-BOND FROM CATALYTIC REDUCTION IN THE PREPARATION OF [1-H-3]MORPHINE AND [1-H-3]CODEINE, Journal of labelled compounds & radiopharmaceuticals, 41(9), 1998, pp. 811-821
Citations number
3
Categorie Soggetti
Chemistry Analytical","Chemistry Medicinal","Biochemical Research Methods","Pharmacology & Pharmacy
The t-butyldimethylsilylation of the allylic alcohol of 1-iodomorphine
and 1-iodocodeine protects the double bond of these molecules from ca
talytic reduction while allowing the reduction of the aryl iodide. Thi
s selectivity has been applied to the preparation of tritiated morphin
e and codeine without complicating over reduction to the dihydromorphi
ne and dihydrocodeine.