Primary tracheal neoplasms are extremely rare lesions in the pediatric
age group. This study reviews the English-language literature to bett
er characterize these lesions in children and reports 2 additional pat
ients. Reports of only 36 infants and children through adolescence wit
h primary tracheal neoplasms were discovered after an exhaustive liter
ature review of the last 30 years. The data are analyzed with regard t
o pathology, demographics, symptomatology, site, and percent luminal o
bstruction. We report 2 additional patients with photographic document
ation, imaging studies, and histopathology. Of the 36 previously repor
ted lesions, 64% were characterized as benign and 36% as malignant. Fi
fty-six percent of all lesions were initially misdiagnosed as asthma.
The most common site was the posterior membranous wall of the cervical
trachea. In 14 (39%) of the 36 patients, the lesions obstructed more
than 50% of the lumen at the time of diagnosis. The timely diagnosis o
f tracheal masses depends upon maintaining a high index of suspicion a
nd conducting an efficient workup, including definitive evaluation by
bronchoscopy. The evaluation and the differential diagnosis of trachea
l neoplasms in the pediatric population is discussed.