During the neonatal period, albumin infusions are administered in resp
onse to a variety of clinical scenarios. Review of currently available
literature, however, demonstrates that crystalloid rather than colloi
d infusions should be used both to treat hypovolaemic hypotension and
as the replacement fluid in a dilutional exchange. The role of an albu
min infusion in ''treating'' metabolic acidosis needs further evaluati
on, but the practice of giving albumin to correct ''asymptomatic'' hyp
oalbuminaemia or at resuscitation should be discouraged.Conclusion The
neonatologist would be well advised, when reaching for an albumin inf
usion, to reflect that there may be a safer, certainly cheaper and equ
ally effective alternative.