Injury to peripheral nerves due to injections of therapeutic and other
agents is common. The postulated mechanisms of injury include direct
needle trauma, secondary constriction by scar, and direct nerve fiber
damage by neurotoxic chemicals in the injected agent. Neurological seq
uelae can range from minor transient sensory disturbance to severe sen
sory disturbance and paralysis with poor recovery. The recommended tre
atment has ranged from a conservative approach to immediate operative
exposure and irrigation, and has also included early neurolysis or del
ayed exploration with neurolysis or resection and anastomosis. We pres
ent 370 cases of injection injury of the sciatic nerve in children tre
ated during the last 20 years at the Neurosurgical Department of the H
ospital La Paz in Madrid, Spain. Pathology, clinical course, treatment
, and results are discussed.