THE EFFECTS OF DENTAL DISEASE ON SYSTEMIC-DISEASE

Chronic exposure to periodontal pathogens results in the continued sti mulation of an immune and nonimmune response by the host. The cytokine s and other inflammatory mediators produced in gingivitis/periodontiti s result in local tissue destruction and may reach significant levels affecting the cardiovascular system or placental tissues. The oral cav ity may also serve as a direct reservoir for bacterial contamination o f the lungs with subsequent development of bacterial pneumonia.