We report on the case of a 24-year-old white man with a history of chr
onic leukemia treated with unrelated bone marrow transplantation and c
hemotherapy who was correctly diagnosed with appendicitis rather than
typhlitis. The approach to diagnosing an acute abdomen in the leukemic
patient is discussed, with particular focus on appendicitis vs. typhl
itis. A focused CT scan proved to be instrumental in making the correc
t diagnosis of appendicitis in our patient. The literature on this top
ic for the past 30 years is reviewed. The purpose of our report is to
demonstrate that despite the recent trend toward diagnosing RLQ pain a
s typhlitis which requires medical management, there are still instanc
es where it 'really is' appendicitis. Appendicitis, therefore, must al
ways be ruled out in the leukemic patient.