ANATOMICAL AND PATHOLOGICAL-STUDY OF RETROPERITONEAL NODES IN ENDOMETRIAL CANCER

To assess the patterns of lymphatic spread in endometrial carcinoma, d ata from 91 endometrial cancer patients (surgical FIGO stage I: 59; II : 12; III-IV: 20) who underwent systematic pelvic and aortic lymphaden ectomy were analyzed. The median number of nodes removed was 27 aortic (range 15-57) and 31 pelvic (range 20-68) nodes. Positive nodes were found in 16 patients (18%), seven having pelvic, one aortic, and eight both pelvic and aortic metastasis. The median number of positive node s was three (range 1-29) aortic and two (range 1-18) pelvic nodes. Iso lated pelvic node metastasis was observed in seven patients and aortic metastasis in one patient. Pre-paracaval, pre-paraortic and intercavo aortic, with superficial obturator, external iliac and common iliac we re the node groups most frequently involved. These nodes may be consid ered primarily invaded by the tumor. The higher prevalence of pelvic w ith respect: to aortic metastasis, and the low risk of isolated aortic spread, suggest that endometrial cancer spreads preferentially to the pelvic area. Multivariate analysis showed that depth of myoinvasion a nd adnexal metastasis were independent factors predicting the risk of lymphatic spread. The risk of aortic spread was also predicted by the pelvic node status. These data may be useful for tailoring lymphadenec tomy.