SURFACTANT PROTEIN-A (SP-A) FORMS A NOVEL SUPRAQUATERNARY STRUCTURE IN THE FORM OF FIBERS

Authors
PALANIYAR N RIDSDALE RA POSSMAYER F HARAUZ G
Citation
N. Palaniyar et al., SURFACTANT PROTEIN-A (SP-A) FORMS A NOVEL SUPRAQUATERNARY STRUCTURE IN THE FORM OF FIBERS, Biochemical and biophysical research communications (Print), 250(1), 1998, pp. 131-136
Citations number
53
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications (Print) → ACNP
ISSN journal
0006291X
Volume
250
Issue
1
Year of publication
1998
Pages
131 - 136
Database
ISI
SICI code
0006-291X(1998)250:1<131:SP(FAN>2.0.ZU;2-0
Abstract
We have found by transmission electron microscopy that bovine surfacta nt protein A (SP-A) formed extended fibers in the presence of calcium. On phosphatidylcholine or especially dipalmitoylphosphatidylcholine m onolayers, SP-A at roughly 0.005 mg/ml formed large numbers of fibers and elaborate fibrous networks. This observation suggested that the we ak protein:protein interactions amongst free SP-As could be stabilized by phospholipids. In the presence of glycolipid G(M1)-ganglioside, SP -A's globular headgroup regions appeared enlarged and only small non-f ibrous clusters were observed. (C) 1998 Academic Press.