Objectives: To observe headache frequency after release for acute migr
aine sufferers treated in an ED; to observe the impact after-release h
eadaches and associated symptoms have on quality of life; and to docum
ent the variability in migraine management in an emergency setting. Me
thods: Prospective observational study, including 24- and 72-hour tele
phone follow-up. Results: Over a 4-month period, 143 patients with hea
daches (149 visits) were observed in the ED. Of 108 patients successfu
lly contacted, the incidence of headache in the first 24 hours after r
elease was 49.1%. Forty-two patients left the ED without pain; 13 of t
hese subsequently had return of headache. Sixty-six left with some deg
ree of pain, with 40 having headache persistence at 24 hours. The diff
erence in 24-hour headache rate between the 2 groups is significant (p
= 0.008). Five patients still had headaches at 72 hours after release
, but 54 of 70 contacted had taken medication for their symptoms betwe
en 24 and 72 hours after release. Forty-five percent were not back to
normal function at 24 hours, while 21 of 70 were still not sleeping we
ll at 72 hours. Finally, 8 different classes of medications were used
in the ED for migraine headaches, with 20 patients receiving at least
3 types of medication. Conclusions: Treatment for acute migraine heada
che in this emergency setting was variable. Patients not obtaining com
plete relief in the ED had a higher rate of headache after release tha
n did those who left with no pain. Migraine sufferers may have normal
daily function affected for up to 72 hours or longer after ED treatmen
t.